Author

Niall Quinn

University College Dublin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Barbara De KegeliD· 2 shared Colm J. RyaniD· 2 shared Alex von KriegsheimiD· 1 shared Alfonso Bolado‐CarrancioiD· 1 shared Anjan VenkateshiD· 1 shared David J. AdamsiD· 1 shared Kieran J. WynneiD· 1 shared Nicola ThompsoniD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSystems Biology

Barbara De KegelORCID

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2 papers

Recent·Most cited

Paralog protein compensation preserves protein-protein interaction networks following gene loss in cancer

Anjan Venkatesh, Niall Quinn, Swathi Ramachandra Upadhya, Barbara De Kegel, Alfonso Bolado‐Carrancio, Thomas Lefeivre, Olivier Dennler, Kieran J. Wynne, Alex von Kriegsheim, Colm J. Ryan

The paper shows that gene loss in cancer is often compensated by paralog protein abundance changes, stabilizing protein-protein interaction networks and creating therapeutic vulnerabilities.

bioRxiv · Sep 26, 2024 · PreprintSystems Biology

Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines

Barbara De Kegel, Niall Quinn, Nicola Thompson, David J. Adams, Colm J. Ryan

The paper predicts synthetic lethal interactions between paralog pairs in cancer cell lines using machine learning and features from CRISPR screens and molecular profiles.

Cell Systems · Sep 15, 2021Peer-reviewedSystems Biology