Cancer BiologybioRxiv
DBD-α4 helix of EWSR1::FLI1 is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma
Ariunaa Bayanjargal, Cenny Taslim, Iftekhar A. Showpnil…·Emily Rose Theisen
This study investigates the role of the DBD-4 helix in EWSR1::FLI1's binding to GGAA microsatellites, showing its importance in genome regulation and oncogenic transformation in Ewing sarcoma.