Emily R. Theisen

This study investigates how EWSR1::FLI1 binds to nucleosomes and DNA motifs, revealing its pioneer factor properties and preference for GGAA repeats.

This study defines the enzymatic and nonenzymatic roles of LSD1 in Ewing sarcoma using genetic and pharmacological approaches, revealing gene repression and its impact on synapse function and e-cadherin targets.

RNA-SeqEZPZ is a user-friendly pipeline for RNA-Seq analysis with interactive visualizations, offering both point-and-click and command-line interfaces for reproducible and customizable transcriptomics workflows.

This study shows NR0B1 alters the 9-cis-retinoic acid response in Ewing Sarcoma cells by modulating nuclear receptor activity, suggesting NR0B1 inhibition could enhance retinoid therapy.

This paper identifies that SP-2509 and SP-2577, LSD1 inhibitors, induce cell death in Ewing sarcoma through Fe-S cluster disruption, independent of LSD1 inhibition.

This study shows seclidemstat inhibits the transcriptional activity of multiple FET fusion oncoproteins in vitro, suggesting it as a promising treatment for FET-rearranged sarcomas.

This study investigates the role of the DBD-4 helix in EWSR1::FLI1's binding to GGAA microsatellites, showing its importance in genome regulation and oncogenic transformation in Ewing sarcoma.