Theodore Papadopoulos

This study identifies PRMT7 as a negative regulator of CD8+ T cell immunity and demonstrates a PROTAC degrader (MS54) that enhances anti-tumor responses by activating the NF-κB pathway.

This study identifies RAB1A as a vulnerability in uveal melanoma through dual inhibition of MNK1/2 and mTOR, showing it disrupts protein trafficking and blocks liver metastasis.