Molecular BiologybioRxivPreprint
The CDKL5 kinase undergoes liquid-liquid phase separation driven by a serine-rich C-terminal region and impaired by neurodevelopmental disease-related truncations
Marco Dell’Oca, Stefania Boggio Bozzo, Serena Vaglietti…·Ferdinando Fiumara
This study shows CDKL5 undergoes liquid-liquid phase separation driven by its C-terminal domain, and disease mutations impair this process, reducing phosphorylation of EB2.
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