Author

Luca Colnaghi

Vita-Salute San Raffaele UniversityORCID 0000-0002-9699-5318Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ferdinando FiumaraiD· 2 shared Andrea AlessandriniiD· 1 shared Antonia GurgoneiD· 1 shared Arun AsokiD· 1 shared Benedetta VaiiD· 1 shared Carmina NataleiD· 1 shared David A. LewisiD· 1 shared Denise Bystryn KandeliD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBioinformatics

Ferdinando FiumaraORCID

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4 papers

Recent·Most cited

CircRNA hypomethylation in the human amygdala implicates FKBP5 in alcohol use disorder

Tara Ghandour, Jill R. Glausier, Arun Asok, Michelle R. Doyle, Paola Campo, Luca Colnaghi, David A. Lewis, Denise Bystryn Kandel, Eric R. Kandel, Giordano de Guglielmo, Shao‐shan Carol Huang, Philippe A. Melas

The paper identifies circRNA hypomethylation in the human amygdala linked to FKBP5 in alcohol use disorder, with replication in an animal model.

bioRxiv · May 4, 2025 · PreprintMolecular Biology

Prognostic and biological roles of Parkinson's disease genes in cancer

Sara Fiume, Francesca Molinari, Benedetta Vai, Sara Poletti, Giovanni Citterio, Ferdinando Fiumara, Stéphanie Papin, Paolo Paganetti, Maurizio Callari, Luca Colnaghi

The paper investigates the association between Parkinson's disease genes and cancer outcomes, finding gene-specific survival correlations and links to cancer hallmarks and drug responses.

bioRxiv · Mar 22, 2025 · PreprintBioinformatics

The CDKL5 kinase undergoes liquid-liquid phase separation driven by a serine-rich C-terminal region and impaired by neurodevelopmental disease-related truncations

Marco Dell’Oca, Stefania Boggio Bozzo, Serena Vaglietti, Antonia Gurgone, Vita Cardinale, Gregorio Ragazzini, Andrea Alessandrini, Luca Colnaghi, Mirella Ghirardi, Maurizio Giustetto, Ferdinando Fiumara

This study shows CDKL5 undergoes liquid-liquid phase separation driven by its C-terminal domain, and disease mutations impair this process, reducing phosphorylation of EB2.

bioRxiv · Nov 18, 2024 · PreprintMolecular Biology

Role of misfolded tau in the onset and progression of brain toxicity after trauma

Elisa Roncati Zanier, Maria Monica Barzago, Gloria Vegliante, Margherita Romeo, Ilaria Bertani, Carmina Natale, Luca Colnaghi, Laura Colombo, Luca Russo, Edoardo Micotti, Luana Fioriti, Roberto Chiesa, Luisa Diomede

This study shows that misfolded tau from traumatic brain injury induces toxicity in C. elegans, suggesting it drives functional decline rather than just being a marker of neurodegeneration.

bioRxiv · Jun 18, 2020 · PreprintNeuroscience