Wataru Koyama

The paper demonstrates the use of microbial rhodopsins and adenylyl cyclases to control second messengers in zebrafish neurons and cardiomyocytes, revealing their roles in locomotion and cardiac function.

The paper develops optogenetic tools using animal G protein-coupled bistable rhodopsins to control Gq and Gi/o signaling in neurons and cardiomyocytes, showing their utility in vivo.