David Orme

This paper introduces coppaFISH 3D and CASTalign to enable transcriptomic identification of thousands of in vivo recorded neurons at scale.

This study introduces a temporally structured olfactory task for mice to isolate relational structure from sensory cues and reward, showing that dopamine prediction errors and ventral hippocampal activity are linked to learned temporal structures.

The paper identifies a transcriptomic axis that predicts how cortical interneurons modulate activity across brain states.