Characterization of the cardiac proteome of wild-type transthyretin amyloidosis cardiomyopathy
Marcus Rhodehamel, Vivek Jani, Ryan Gross, Krish C. Dewan, Atharva R. Mulay, Navid Koleini, Matthew W. Foster, Kavita Sharma, Mohammed Aslam, Joban Vaishnav, Dawn E. Bowles, David A. Kass, Mark John Ranek
The paper identifies unique proteomic changes in ATTR-CM hearts, showing upregulated endocytosis and downregulated sarcomere proteins compared to controls.
bioRxiv · Sep 29, 2025 · PreprintMolecular Biology