Kavita Sharma

Myeloid cell recruitment propels right ventricular dysfunction in HFpEF via sterile inflammation.

This paper shows that myeloid cell recruitment drives right ventricular dysfunction in HFpEF through sterile inflammation in both mice and humans.

Targeted measurement of blood flow in the Anterior Cerebral Artery using Diffuse Correlation Spectroscopy

This paper demonstrates a method to measure blood flow in the Anterior Cerebral Artery using Diffuse Correlation Spectroscopy with optimized probe geometry and placement.

Reduced Myocardial Serine Synthesis Impairs Functional, Metabolic, and Redox Adaptations to Cardiac Stress

This study shows that reduced myocardial serine synthesis impairs cardiac stress responses by disrupting redox balance, one-carbon metabolism, and amino acid homeostasis.

Multicenter HFpEF study identifies sex disparity linked with two discrete cardiac proteomic signatures

This study identifies two distinct cardiac proteomic signatures in HFpEF linked to sex ratios, revealing molecular differences in structural machinery and cellular communication.

Characterization of the cardiac proteome of wild-type transthyretin amyloidosis cardiomyopathy

The paper identifies unique proteomic changes in ATTR-CM hearts, showing upregulated endocytosis and downregulated sarcomere proteins compared to controls.

Random survival forests identify myocardial gene signatures associated with survival in heart failure with preserved ejection fraction

The paper uses random survival forests to identify 33 myocardial genes predictive of survival in HFpEF, outperforming clinical parameters in prognosis modeling.

Single cell transcriptomic analyses of human heart failure with preserved ejection fraction

This paper uses snRNA-seq to analyze human HFpEF myocardium, identifying differential gene expression and pathway enrichment in cardiomyocytes and fibroblasts compared to controls and DCM.

ATP Citrate Lyase Supports Cardiac Function and NAD+/NADH Balance And Is Depressed in Human Heart Failure

This study investigates the role of ATP citrate lyase (ACLY) in cardiac function and NAD+/NADH balance, finding it is reduced in heart failure and its inhibition impairs cardiac function and metabolism.