Dawn E. Bowles

The paper investigates the role of cardiac myofibroblasts and UCP2 SNPs in right ventricular failure in pulmonary arterial hypertension, finding increased cMFB and reduced UCP2 associated with decompensation.

This study identifies PTBP1 as a key regulator of endothelial dysfunction in cardiac allograft vasculopathy, showing its deletion reduces fibrosis and immune activation in mouse models.

This study shows that neddylation regulates mitochondrial dynamics and turnover in the adult heart, linking its disruption to cardiomyopathy and heart failure.

The paper identifies unique proteomic changes in ATTR-CM hearts, showing upregulated endocytosis and downregulated sarcomere proteins compared to controls.

This study identifies conserved polyploidy asymmetry between cardiac chambers in Drosophila and humans, showing its role in maintaining heart function and its implications for heart failure.