PhysiologyFEBS JournalPeer-reviewed
Metformin protects the heart against chronic intermittent hypoxia through AMPK-dependent phosphorylation of HIF-1α
Sophie Moulin, Britanny Blachot‐Minassian, Anita E. M. Kneppers…·Elise Belaïdi
This study shows metformin protects the heart from chronic intermittent hypoxia by activating AMPK2, which phosphorylates and inhibits HIF-1α, reducing mitochondrial damage.
9 citations