Anita E. M. Kneppers

This paper shows that delivering AMPK activator 991 via polymeric nanoparticles reduces toxicity and improves muscle homeostasis in a DMD mouse model.

This study shows metformin protects the heart from chronic intermittent hypoxia by activating AMPK2, which phosphorylates and inhibits HIF-1α, reducing mitochondrial damage.

This study identifies the AMPK2/PHF2 axis as essential for lipid droplet turnover in muscle stem cells during regeneration, showing that PHF2 promotes lipid droplet-mitochondria contact.

The paper develops an ex vivo model of nerve-induced skeletal muscle contraction to study its endocrine and paracrine responses and effects on cell types.

This study shows that Cre recombinase activation in skeletal muscle stem cells impairs muscle regeneration, highlighting off-target effects of Pax7CreERT2 mice.