Yuqin Gu

The paper conducts a multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycemic traits, identifying novel loci and highlighting limited pregnancy-specific genetic effects.

This study identifies a SOX8-USP7-PGC-1α regulatory axis in brown adipocytes that enhances thermogenesis but also causes metabolic maladaptation with prolonged activation.

The paper identifies 4,688 genome-wide significant loci for 111 gestational phenotypes and finds dynamic genetic effects linked to maternal health outcomes.

The paper develops methods for analyzing low-depth NIPT sequencing data to accurately estimate allele frequencies and genetic effect sizes, enabling population genetic studies.

This study performs GWAS on thyroid traits in Chinese pregnancies, identifying 176 genetic loci and linking thyroid function to pregnancy complications and later health outcomes.

This study identifies East Asian-specific genetic loci for intrahepatic cholestasis of pregnancy linked to historical HBV infection, using genome-wide association analyses in 101,023 Chinese women.

This study identifies four genetic loci associated with gestational diabetes risk and 31 loci linked to glycaemic traits in 30,699 Chinese pregnant women, with MTNR1B showing the strongest association.