Author

David M. Reyes-Aguilar

Georgia Institute of TechnologyORCID 0009-0006-0426-526XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Ankur K. SinghiD· 1 shared Cheng ZhuiD· 1 shared Hyun-Kyu ChoiiD· 1 shared Jintian Lyu· 1 shared Jürgen WienandsiD· 1 shared Matthias MünchhalfeniD· 1 shared Richard GörgiD· 1 shared Stefano TravaglinoiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

Ankur K. SinghORCID

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1 paper

Recent·Most cited

ImmunologyScience AdvancesPeer-reviewedNov 15, 2024

Mechanotransduction governs CD40 function and underlies X-linked Hyper IgM syndrome

Hyun-Kyu Choi, Stefano Travaglino, Matthias Münchhalfen…·Cheng Zhu

This study shows that CD40-CD40L interactions form catch bonds that enhance B cell signaling and antibody class-switch, and mutations in CD40L disrupt this mechanism, causing X-linked Hyper IgM syndrome.

22 citations

humanproteomics

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