Christopher Parperis

The paper presents a presynapse-on-glass model to study presynaptic actin architecture, showing actin enrichment correlates with synaptic cycling activity and identifies actin nanostructures.

The paper shows spectrin condensates facilitate the formation of the periodic axonal structure by acting as local assembly hubs that later develop into a stable lattice.

The paper identifies non-synaptic exocytosis along axon shafts and shows how the submembrane actin-spectrin skeleton regulates this process.

This study investigates the developmental program and functional properties of axon-carrying-dendrite neurons, revealing unique features of their axon initial segment.