Feng Shi

The paper uses cis mutations in Dscam1 to show noncanonical roles of isoform diversity in neuronal wiring, revealing distinct phenotypic defects in different neuron types.

The paper shows that reduced Dscam1 isoform diversity, not just self-avoidance, causes defects in mushroom body axonal wiring in Drosophila.

The paper shows that specific Dscam1 isoform splicing biases are required for precise mushroom body axonal wiring in Drosophila, with variable domain-specific effects.