BiochemistrybioRxiv
Atom-economic enantioselective photoenzymatic radical hydroalkylation via single-electron oxidation of carbanions
Jin Zhu, Qiaoyu Zhang, Tao Gu…·Yajie Wang
This paper introduces a photoenzymatic system for enantioselective hydroalkylation of C(sp3)-H bonds using a flavin-dependent ene-reductase and fluorescein, achieving atom-economic and enantiodivergent reactions.
DOI 10.1038/s41929-025-01434-2