Xiao Liu

Cross-modal transfer enables zero-shot prediction of drug responses across cell types

GRAFT predicts drug responses across cell types without direct measurements by transferring genetic perturbation data to chemical perturbations.

Isolation, extraction, and physicochemical characterization of exosome-like nanovesicles from ginseng adventitious roots in tissue culture

This study isolates and characterizes exosome-like nanovesicles from ginseng adventitious roots and shows that MeJA increases their yield and active components.

SERINC1-dependent lipid preservation gates neocortical synaptogenesis and remote memory

This study identifies SERINC1 as a lipid regulator critical for neocortical synaptogenesis and remote memory by preserving specific phospholipids during memory consolidation.

Three-dimensional Virtual Adult Cardiomyocyte Transcriptomics

This paper introduces 3D-VirtualCM, a method to reconstruct full cardiomyocyte transcriptomes from spatial transcriptomic sections, revealing spatial and transcriptional heterogeneity in infarcted mouse hearts.

Early menopause is associated with reduced global brain activity

This study finds that early menopause is associated with reduced global brain activity and weaker coupling to CSF flow, linked to memory decline and increased dementia risk.

Robust Conditional Diffusion with Noisy Templates for Antibody Sequence-Structure Design

This paper introduces NT-ABDiff, a diffusion model for antibody sequence-structure design that improves CDR recovery and structural accuracy using noisy and unreliable templates.

Metal Coordination Dynamics Governs Selective Epoxidation in Hyoscyamine 6β-Hydroxylase: Integrated Experimental and Computational Insights

This paper investigates the catalytic mechanism of hyoscyamine 6β-hydroxylase, revealing that metal coordination dynamics govern selectivity between hydroxylation and epoxidation reactions.

Harnessing Human Immune Organoid model for Systemic and Comparative Analysis of Clinically Vaccine Adjuvants

This study evaluates clinically relevant vaccine adjuvants using a human immune organoid model, identifying AddaSO3 as consistently effective across early and prolonged immune response phases.

SpaCir-VDJ: a broadly compatible circularization strategy for spatial immune repertoire profiling

SpaCir-VDJ enables spatial immune repertoire profiling by integrating spatial barcodes and V(D)J sequences into circular templates, revealing clonal organization and somatic hypermutation patterns in human tissues and gastric cancer.

Multicopper oxidase mediated single-carbon insertion for skeletal remodeling

This paper introduces a multicopper oxidase-catalyzed method for single-carbon insertion in skeletal editing, enabling the synthesis of bioactive compounds with improved antibacterial activity.

Atom-economic enantioselective photoenzymatic radical hydroalkylation via single-electron oxidation of carbanions

This paper introduces a photoenzymatic system for enantioselective hydroalkylation of C(sp3)-H bonds using a flavin-dependent ene-reductase and fluorescein, achieving atom-economic and enantiodivergent reactions.

Propagating cortical waves coordinate sensory encoding and memory retrieval in the human brain

The paper shows that human brain activity alternates between exteroceptive and interoceptive states through propagating fMRI waves, coordinating sensory encoding and memory retrieval.

Necroptosis promotes the Aging of the Male Reproductive System in Mice

This study shows that necroptosis in testes accelerates aging of the male reproductive system in mice by promoting cellular deterioration.