Author

Takehito Seki

National Institutes of Natural SciencesORCID 0009-0006-1830-8566Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Kei-ichi OkazakiiD· 2 shared Blanca BarqueraiD· 1 shared Hideto MiyoshiiD· 1 shared Jun OhnukiiD· 1 shared Jun-ichi KishikawaiD· 1 shared Masatoshi MuraiiD· 1 shared Moe IshikawaiD· 1 shared Takahiro MasuyaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

Kei-ichi OkazakiORCID

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2 papers

Recent·Most cited

BiophysicsJournal of Chemical Information and ModelingPeer-reviewedApr 3, 2026

Conformational Dynamics of Na+-Pumping NADH-Quinone Oxidoreductase during Na+ Translocation from AlphaFold-Facilitated Markov State Modeling

Takehito Seki, Jun Ohnuki, Kei-ichi Okazaki

This study uses AlphaFold and Markov state modeling to analyze the conformational dynamics of Na+-NQR, revealing how redox state and Na+ binding regulate Na+ translocation.

1 citation

bacteria (other)structural biology

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BiochemistrybioRxivPreprintJun 1, 2025

The Na+-pumping mechanism driven by redox reactions in the NADH-quinone oxidoreductase from Vibrio cholerae relies on dynamic conformational changes

Moe Ishikawa, Takehito Seki, Jun-ichi Kishikawa…·Masatoshi Murai

This study identifies five conformational states of Na+-NQR in Vibrio cholerae using mutants and inhibitors, revealing that 2Fe-2S reduction drives Na+ translocation through structural rearrangements.

2 citations

bacteria (other)structural biology

𝕏 PostBluesky