Author

Shalini K. Wijerathne

Institute of Biochemistry, Molecular Biology and BiotechnologyORCID 0009-0006-2859-4420Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:rat· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Kanishka Sithira SenathilakeiD· 4 shared Sameera R. SamarakooniD· 4 shared Sandani De Vass Gunawardane· 3 shared Arumugam Murugananthan· 2 shared Epitawala Arachchige Oshadi· 2 shared Kamani Hemamala TennekooniD· 2 shared Anusha Kanagasundaram· 1 shared Ashein Kothalawala· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersPharmacology & Toxicology

Kanishka Sithira SenathilakeORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

BioinformaticsPLoS ONEPeer-reviewedJul 1, 2026

A network pharmacology-based approach and molecular docking study to explore the therapeutic potential of a nutraceutical formula (Vernolac) in the treatment of cancer

Sandani De Vass Gunawardane, Matheen Muhammadh Milhan, Poorni Chanuka Rathnayaka…·Sameera R. Samarakoon

This study uses network pharmacology and molecular docking to explore Vernolac's anticancer mechanisms, identifying key phytochemicals and pathways involved in apoptosis, immune modulation, and chemoradiosensitization.

2 citations

statistical modelmachine learning (classical)

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintApr 1, 2026

In vivo pharmacokinetics and tissue distribution profile of a Wnt/β-catenin pathway-targeting anticancer cassane diterpene isolated from Caesalpinia pulcherrima

Sandani De Vass Gunawardane, Epitawala Arachchige Oshadi, Shalini K. Wijerathne…·Kanishka Sithira Senathilake

This study reports the pharmacokinetics and tissue distribution of 6βCHV in rats after oral administration, showing delayed absorption and wide tissue distribution.

DOI 10.64898/2026.03.30.715187

ratstatistical model

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintDec 30, 2025

Preclinical Safety Evaluation of Vernolac, a Commercially Available Polyherbal Nutraceutical Comprising Vernonia zeylanica, Nigella sativa, Hemidesmus indica, Smilax glabra, and Leucas zeylanica, in Wistar Rats

Shalini K. Wijerathne, Epitawala Arachchige Oshadi, Sandani De Vass Gunawardane…·Sameera R. Samarakoon

This study evaluates the acute and 28-day repeat-dose toxicity of Vernolac in Wistar rats, finding no significant toxicity at up to four times the therapeutic dose.

DOI 10.64898/2025.12.27.696713

ratexperimental assay

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintSep 8, 2025

Anti-proliferative and Apoptosis Inducing Effect of Thymoquinone in Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells

Rajitha Kalum Rathnayaka, Fathima T. Muhinudeen, Nirwani Natasha Seneviratne…·Sameera R. Samarakoon

This study evaluates thymoquinone's anti-proliferative and pro-apoptotic effects on NTERA-2 cancer stem-like cells and PBMCs, showing dose- and time-dependent inhibition of proliferation and increased apoptosis.

DOI 10.1101/2025.09.08.674795

humanbulk RNA-seq

𝕏 PostBluesky