Sai Shyam

The paper introduces a framework to analyze gene regulatory networks by identifying mutually inhibiting teams of nodes and shows how network topology predicts dynamic behavior.

This study identifies nicotinamide metabolism as a key modulator of IFN-gamma and nitric oxide responses through transcriptomic and metabolic analysis in macrophages.

The paper analyzes the antagonistic roles of RKIP and BACH1 in cancer cell plasticity using transcriptomic data and a gene regulatory network model, showing their association with EMT, metabolic reprogramming, immune evasion, and clinical outcomes.