Soundharya Ramu

The paper develops a mathematical model showing that Androgen Receptor stabilizes a hybrid epithelial/mesenchymal phenotype in prostate cancer cells with Notch-Jagged signaling, correlating with worse patient outcomes.

ONCOchannelome identifies altered ion channels in tumors using transcriptomic data, revealing their correlation with metastasis and biological changes.

The paper shows that interconnected axes of phenotypic plasticity in breast cancer drive coordinated cellular behavior and influence clinical outcomes through mutual inhibition between two teams of plasticity-related nodes.

The paper analyzes the antagonistic roles of RKIP and BACH1 in cancer cell plasticity using transcriptomic data and a gene regulatory network model, showing their association with EMT, metabolic reprogramming, immune evasion, and clinical outcomes.

The paper uses multi-modal transcriptomic data to show basal breast cancer exhibits hybrid epithelial/mesenchymal states and higher phenotypic heterogeneity compared to luminal breast cancer.