Emma M. Peacock

This study shows FBH1 reverses replication forks through sequential unwinding of nascent strands without forming four-way junctions, distinct from other reversal factors.

This study reveals how SCFFBH1 promotes fork reversal and regulates RAD51 through DNA binding and ubiquitination, using cryo-EM structures and in vitro experiments.

This paper shows that HLTF has two roles in managing G4s: preventing their accumulation and slowing replication forks to maintain genome stability.