Subhasri Ghosh

This study investigates how substituting the azadithiolate ligand in ToHydA affects O2-stability by preventing the formation of specific states and altering structural dynamics.

This study uses molecular simulations and mutagenesis to investigate the role of an additional cysteine in enhancing H2 production activity of ToHydA without affecting O2 stability.

This study identifies ToHydA, an O2-stable [FeFe]-hydrogenase from Thermosediminibacter oceani, and reveals structural features that protect the H-cluster from O2-induced degradation.