Lukas Kiwitz

SPARQ-MI provides a streamlined spatial single-cell analysis method for tumor microenvironments, revealing CD8 T cell state and spatial location associations with immunotherapy response.

This study examines neutrophil infiltration patterns in lymph nodes during adoptive T cell therapy in mice, revealing differences between tumor-draining and non-tumor-draining lymph nodes.

This study uses simulations to show that spatial cytokine inhomogeneities in T cell populations are critical for paracrine signaling and depend on cell population properties and feedback mechanisms.

This study uses a spatial reaction-diffusion model to show that cytokine secretion patterns and receptor expression feedback shape spatial cytokine gradients in tissues.