Maiia Shulman

This study shows TNF-α disrupts the malate-aspartate shuttle in iPSC-derived enteric neural cells from PD patients, causing metabolic shifts and mitochondrial dysfunction, which can be reversed by targeting glutamate metabolism.

The paper creates a Human Cytokine Dictionary using single-cell transcriptomes of PBMCs stimulated with cytokines, revealing cell-type-specific responses and communication networks.

This paper introduces a VAE-based model for integrating multimodal single-cell data, showing it can map queries across modalities and improve data imputation and biological discovery.

Spapros selects optimal probe sets for targeted spatial transcriptomics to improve cell type identification and spatial variation detection across multiple datasets.