Acute immune modulation with poly-salicylic acid particles ameliorates pain and structural damage in post-traumatic osteoarthritis
Michael L. Felder, Lindsey Lammlin, Adrienne A. Giannone, Maria Valentina Guevara, Scarlet C. Howser, Isabelle J. Smith, Omolola Eniola‐Adefeso, Tristan Maerz
This study shows that PolySA particles reduce immune cell recruitment and alleviate pain and structural damage in post-traumatic osteoarthritis in female mice but not males.
bioRxiv · Nov 21, 2025 · PreprintBioengineering