Scarlet C. Howser

PIEZO1 mediates mechanosensing and myofibroblastic activation of synovial fibroblasts in post-traumatic osteoarthritis

This study identifies PIEZO1 as a critical mediator of myofibroblast activation and fibrosis in post-traumatic osteoarthritis through mechanosensing mechanisms.

Thrombospondin-2 deficiency primes the synovial joint for aberrant tissue remodeling and injury response

This study shows that TSP2 deficiency leads to increased joint inflammation and worsened osteoarthritis after injury, suggesting TSP2's role in joint homeostasis.

Spatial transcriptomic profiling of decalcified murine musculoskeletal samples via Xenium Prime 5K

This paper develops a sample processing pipeline for spatial transcriptomics of murine musculoskeletal tissues, achieving high-quality transcript detection across multiple tissue types using the Xenium Prime 5K platform.

Acute immune modulation with poly-salicylic acid particles ameliorates pain and structural damage in post-traumatic osteoarthritis

This study shows that PolySA particles reduce immune cell recruitment and alleviate pain and structural damage in post-traumatic osteoarthritis in female mice but not males.

A standardized, open-source, portable model for noninvasive joint injury in mice

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

CXCL16 mediates nociception and inflammation in murine post-traumatic osteoarthritis

This study shows CXCL16 drives synovial inflammation and joint pain through CXCR6, suggesting it as a target for treating post-traumatic osteoarthritis.