Lindsey Lammlin

This study identifies PIEZO1 as a critical mediator of myofibroblast activation and fibrosis in post-traumatic osteoarthritis through mechanosensing mechanisms.

This study shows that TSP2 deficiency leads to increased joint inflammation and worsened osteoarthritis after injury, suggesting TSP2's role in joint homeostasis.

This paper develops a sample processing pipeline for spatial transcriptomics of murine musculoskeletal tissues, achieving high-quality transcript detection across multiple tissue types using the Xenium Prime 5K platform.

This study shows that repeated NGF injections into mouse knees cause multiple OA-like features without cartilage damage.

This study shows that PolySA particles reduce immune cell recruitment and alleviate pain and structural damage in post-traumatic osteoarthritis in female mice but not males.

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

This study shows CXCL16 drives synovial inflammation and joint pain through CXCR6, suggesting it as a target for treating post-traumatic osteoarthritis.

The paper examines nociceptor sprouting in four mouse models of knee OA, finding progressive neuroplasticity associated with joint damage across different stages of the disease.