Author

Matthew R Smutny

Case Western Reserve UniversityORCID 0009-0006-7111-8331Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Annaelle M. Djomo· 1 shared Charlotte A Connamacher· 1 shared Leah A. GatesiD· 1 shared Matthew Robert PauliD· 1 shared Thomas CarrolliD· 1 shared Tohfa KabiriD· 1 shared Zara NadeemiD· 1 shared Zoe K LawleriD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperCell Biology

Annaelle M. Djomo

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1 paper

Recent·Most cited

Short chain fatty acids regulate the chromatin landscape and distinct gene expression changes in human colorectal cancer cells

Tohfa Kabir, Charlotte A Connamacher, Zara Nadeem, Matthew Robert Paul, Matthew R Smutny, Zoe K Lawler, Annaelle M. Djomo, Thomas Carroll, Leah A. Gates

This study shows SCFAs regulate chromatin modifications and gene expression in human colorectal cancer cells, with butyrate driving gene regulatory effects independent of HDAC inhibition.

bioRxiv · May 7, 2025 · PreprintCell Biology