Thomas Carroll

Short-term gonadal cultures are sufficient for germline transmission in a songbird

This study shows that short-term gonadal cultures of zebra finch PGCs can produce germline chimeras and validated offspring, despite being heterogeneous, unlike long-term chicken PGC cultures.

Identifying phenotype-genotype-function coupling in 3D organoid imaging using Shape, Appearance and Motion Phenotype Observation Tool (SPOT)

The paper develops SPOT, a tool for analyzing 3D morpho-dynamics from 2D live-cell imaging, and applies it to organoids to identify phenotype-genotype-function relationships.

Short chain fatty acids regulate the chromatin landscape and distinct gene expression changes in human colorectal cancer cells

This study shows SCFAs regulate chromatin modifications and gene expression in human colorectal cancer cells, with butyrate driving gene regulatory effects independent of HDAC inhibition.

ELAVL3 regulates splicing of RNAs encoding synaptic signaling proteins in D1 and D2 striatal medium spiny neurons.

The paper identifies ELAVL3 as a key RNA-binding protein regulating alternative splicing of synaptic signaling proteins in D1 and D2 striatal medium spiny neurons.