Author

Leah A. Gates

Case Western Reserve UniversityORCID 0000-0001-6850-8167Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Matthew Robert PauliD· 2 shared Zara NadeemiD· 2 shared Agata L. PatriotisiD· 1 shared Alireza Khademi· 1 shared Amy E. KeatingiD· 1 shared Annaelle M. Djomo· 1 shared Arianna Arroyo-Ortega· 1 shared Benjamin A. GarciaiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

Matthew Robert PaulORCID

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Author profile →

3 papers

Recent·Most cited

Multiomic screening platform uncovers the impact of histone mutations on chromatin and cell fate

Ziyang Ye, Alireza Khademi, Renée Louane Barbosa, Foster Birnbaum, Margaret R. Brown, Colin E Fowler, Arianna Arroyo-Ortega, Daniel Lee, Lijuan Feng, Leah A. Gates, Agata L. Patriotis, Amy E. Keating, Francisco J. Sánchez Rivera, Yadira M. Soto‐Feliciano

This study develops CHANCLA, a multiomic platform to screen oncohistones, revealing their impact on chromatin and cell fate through functional and structural analyses.

bioRxiv · Apr 17, 2026 · PreprintCancer Biology

Short chain fatty acids regulate the chromatin landscape and distinct gene expression changes in human colorectal cancer cells

Tohfa Kabir, Charlotte A Connamacher, Zara Nadeem, Matthew Robert Paul, Matthew R Smutny, Zoe K Lawler, Annaelle M. Djomo, Thomas Carroll, Leah A. Gates

This study shows SCFAs regulate chromatin modifications and gene expression in human colorectal cancer cells, with butyrate driving gene regulatory effects independent of HDAC inhibition.

bioRxiv · May 7, 2025 · PreprintCell Biology

Microbiota-dependent histone butyrylation in the mammalian intestine

Leah A. Gates, Bernardo Sgarbi Reis, Peder J. Lund, Matthew Robert Paul, Marylène Leboeuf, Zara Nadeem, Tom S. Carroll, Benjamin A. Garcia, Daniel Mucida, C. David Allis

The paper shows that histone butyrylation in intestinal epithelial cells is regulated by microbiota and the metabolite tributyrin, and is linked to gene expression.

bioRxiv · Sep 29, 2022 · PreprintMolecular Biology