Matthew Robert Paul

This study shows that H3K27me3 maintenance in mature neurons via EZH1 has minimal impact on gene expression and chromatin accessibility.

This study identifies G-quadruplexes as a source of genome instability in BRCA2-deficient granule cell progenitors and medulloblastoma, suggesting PIF1 helicase as a therapeutic target.

This study shows SCFAs regulate chromatin modifications and gene expression in human colorectal cancer cells, with butyrate driving gene regulatory effects independent of HDAC inhibition.

The paper investigates CAG repeat expansions and their association with cell death in specific brain regions in Huntington's disease using molecular profiling.

The paper identifies layer 5a corticostriatal neurons as selectively vulnerable in Huntington's disease using single nucleus RNA sequencing and shows they have extensive mHTT-CAG expansions.

The paper shows that histone bivalency regulates the timing of cerebellar granule cell development by controlling gene expression during migration and differentiation.

The paper shows that histone butyrylation in intestinal epithelial cells is regulated by microbiota and the metabolite tributyrin, and is linked to gene expression.

This study shows that acute condensin depletion in yeast causes genome decompaction without affecting global gene expression levels.