S. Tansu Bagdatli

The paper uses anti-phage defense systems to block viral lifecycle stages and reveals that PLE activation depends on progressive transcriptional cues from the phage's developmental program.

This study uses ATAC-seq to map the chromatin accessibility of Haloferax volcanii and finds that promoter accessibility does not correlate with transcriptional activity, and archaeal chromatin is similarly accessible to eukaryotic chromatin.

The paper introduces a method to profile off-target specificity of CRISPR enzymes using ssDNA mapping, applicable to both catalytically dead and active Cas9 variants.

ArchR, an HDF5-backed R suite for end-to-end scATAC-seq analysis, outpaces SnapATAC and Signac and processes over 1.2 million simulated cells within 8 h on a laptop.

The paper uses single-cell epigenomic data to identify functional SNPs associated with Alzheimer's and Parkinson's disease, revealing novel gene-disease associations and regulatory mechanisms.