Author

Sarah E. Pierce

Stanford MedicineORCID 0000-0002-9145-9559Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:scATAC-seq· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Approach:benchmark study· 1

Frequent Co-Authors

William James GreenleafiD· 4 shared Jeffrey M. GranjaiD· 3 shared Howard Y. ChangiD· 2 shared M. Ryan CorcesiD· 2 shared Anne Kathrin VossiD· 1 shared Anne Lynn S. ChangiD· 1 shared Ansuman T. SatpathyiD· 1 shared Brett N. Olsen· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersGenomics

William James GreenleafORCID

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4 papers

Recent·Most cited

Functional mapping of epigenetic regulators uncovers coordinated tumor suppression by the HBO1 and MLL1 complexes

Yuning J. Tang, Haiqing Xu, Nicholas W. Hughes, Paloma A. Ruiz, Samuel H. Kim, Emily G. Shuldiner, Steven S. Lopez, Jess D. Hebert, Saswati Karmakar, Laura Andrejka, Deniz Nesli Dolcen, Gábor Zoltán Boross, Pauline Chu, Christian A. Kunder, Colin R. Detrick, , Monte M. Winslow

The paper identifies HBO1 and MLL1 complexes as key tumor suppressors in lung cancer using in vivo functional screens of epigenetic regulators.

Cancer Discovery · Sep 25, 2025Peer-reviewedCancer Biology

High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer

Sarah E. Pierce, Jeffrey M. Granja, William James Greenleaf

The paper introduces Spear-ATAC, a high-throughput scATAC-seq protocol that identifies regulatory networks in cancer by analyzing chromatin accessibility and sgRNA spacer sequences from thousands of cells.

Nature Communications · May 20, 2021Peer-reviewedGenomics

ArchR: An integrative and scalable software package for single-cell chromatin accessibility analysis

Jeffrey M. Granja, M. Ryan Corces, Sarah E. Pierce, S. Tansu Bagdatli, Hani Choudhry, Howard Y. Chang, William James Greenleaf

ArchR, an HDF5-backed R suite for end-to-end scATAC-seq analysis, outpaces SnapATAC and Signac and processes over 1.2 million simulated cells within 8 h on a laptop.

Nature Genetics · Feb 25, 2021Peer-reviewedGenomics✦ In-depth digest

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

Ansuman T. Satpathy, Jeffrey M. Granja, Kathryn E. Yost, Yanyan Qi, Francesca Meschi, Geoffrey P. McDermott, Brett N. Olsen, Maxwell R. Mumbach, Sarah E. Pierce, M. Ryan Corces, Preyas Shah, Jason C. Bell, Darisha Jhutty, Corey M. Nemec, Jean Wang, , Howard Y. Chang

The paper uses scATAC-seq to analyze chromatin accessibility in immune cell development and tumor microenvironments, identifying regulatory elements and trajectories associated with cell differentiation and therapy response.

Nature Biotechnology · Aug 1, 2019Peer-reviewedGenomics