Author

Melinda Pohle

University of SheffieldORCID 0009-0006-9129-6186Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam J. BrowniD· 2 shared Edward CurryiD· 2 shared George Muir· 1 shared John B. RaffertyiD· 1 shared Martyn E. HulleyiD· 1 shared Ryan Holden· 1 shared Suzanne J. GibsoniD· 1 shared Svetlana E. Sedelnikova· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 20 mutual co-author links

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2 shared papersBioengineering

Adam J. BrownORCID

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2 papers

Recent·Most cited

BioengineeringNucleic Acids ResearchPeer-reviewedJul 19, 2025

Synthetic G-quadruplex components for predictable, precise two-level control of mammalian recombinant protein expression

Melinda Pohle, Edward Curry, Ryan Holden…·Adam J. Brown

This paper develops synthetic G-quadruplex elements to precisely control mammalian recombinant protein expression across different hosts and molecular formats.

4 citations

humanexperimental assay

𝕏 PostBluesky

BioengineeringBiotechnology JournalPeer-reviewedJun 1, 2024

Expanding the RNA polymerase biocatalyst solution space for mRNA manufacture

Edward Curry, Svetlana E. Sedelnikova, John B. Rafferty…·Adam J. Brown

This paper expands the RNA polymerase biocatalyst solution space for mRNA manufacture by identifying and validating eight novel RNAPs and their promoters through a high-throughput screening platform.

9 citations

bulk RNA-seqdeep learning

𝕏 PostBluesky