Molecular BiologyFrontiers in Molecular BiosciencesPeer-reviewed
AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity
Laura Perna, Matteo Castelli, Elena Frasnetti…·J. Paul Chapple
The paper uses AlphaFold to predict the structure of sacsin's Hsp90-like domains and identifies key residues for ATPase activity, suggesting sacsin functions as an ATP-driven molecular chaperone.
6 citations