Jiayi Yuan

The paper analyzes single-nucleus RNA-seq data from the human striatum and prefrontal cortex to study inter-individual variation in cell abundances and gene expression, finding age-related changes and genetic associations.

The paper integrates genetic, transcriptomic, and structural data to show that Ca2+ dysregulation via ATP2B2 missense variants contributes to neuropsychiatric disorders.

EpiMII improves MHC-II epitope and neoantigen design by integrating structural features with graph neural networks, achieving higher accuracy and in vivo efficacy in tumor models.