Alec Wysoker

Sibling chimerism among microglia in marmosets

The paper identifies sibling-derived chimerism in microglia and macrophages across marmoset tissues using single-cell RNA-seq, showing hematopoietic origin and regional variation in brain microglia.

Common variation of cell abundances and gene expression in the human striatum

The paper analyzes single-nucleus RNA-seq data from the human striatum and prefrontal cortex to study inter-individual variation in cell abundances and gene expression, finding age-related changes and genetic associations.

Concerted neuron-astrocyte gene expression declines in aging and schizophrenia

The paper identifies a neuron-astrocyte gene expression program, SNAP, that declines in aging and schizophrenia, linking it to cognitive function and genetic risk factors.

A marmoset brain cell census reveals influence of developmental origin and functional class on neuronal identity

The paper analyzes single-nucleus RNA sequencing data from marmoset brain cells to show that neuronal identity is more influenced by developmental origin than functional class.

Ascertaining cells' synaptic connections and RNA expression simultaneously with massively barcoded rabies virus libraries

The paper introduces SBARRO, a method that maps synaptic connections and RNA expression in neurons using barcoded rabies virus and single-cell RNA sequencing, revealing cell-type-specific synaptic networks in mouse brain cells.

Innovations in Primate Interneuron Repertoire

The paper profiles interneurons in primates and rodents to identify evolutionary innovations in brain cell types and their molecular features.

Insights about variation in meiosis from 31,228 human sperm genomes

The paper analyzes 31,228 human sperm genomes to study meiotic variation, finding differences in aneuploidy rates and crossover patterns across donors and gametes.

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

This study identifies nine distinct microglial states in mice across lifespan and after injury using single-cell RNA sequencing, revealing persistent and age-related changes.

A Single-Cell Atlas of Cell Types, States, and Other Transcriptional Patterns from Nine Regions of the Adult Mouse Brain

This paper constructs a single-cell atlas of the adult mouse brain, identifying 565 transcriptionally distinct cell groups and revealing new insights into neuronal specialization and brain organization.