Author

Zhiwei Feng

University of PittsburghORCID 0000-0001-6533-8932Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:deep learning· 1 Approach:graph neural network· 1 Assay:organoid / primary culture· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Bingrui ZhouiD· 1 shared Chris Perrone· 1 shared Cory Shetler· 1 shared Dimiter Stanchev DimitroviD· 1 shared Hong ZhaoiD· 1 shared Jianbing MuiD· 1 shared Jiayi YuaniD· 1 shared Jingxuan GeiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCell Biology

Bingrui ZhouORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Potent and Broad HIV-1 Neutralization by a Bispecific CD4-CD4i Fusion Protein based on Single-Domain CD4-D1 and X5 CD4i antibody

Xiaojie Chu, Cory Shetler, Zeyu Sun, Chris Perrone, Zhiwei Feng, Kerri J. Penrose, Richard Brad Jones, John W. Mellors, Dimiter Stanchev Dimitrov, Wei Li

The paper designs a bispecific CD4-CD4i fusion protein that broadly neutralizes diverse HIV-1 subtypes with potency comparable to broadly neutralizing antibodies.

bioRxiv · Apr 25, 2026 · PreprintMolecular Biology

EpiMII: Integrating Structure and Graph Neural Networks for MHC-II Epitope and Neoantigen Design

Jiayi Yuan, Xiaowei Xu, Ze‐Yu Sun, Tianjian Liang, Jingxuan Ge, Ruofan Jin, Xiang‐Qun Xie, Yan Chen, Tingjun Hou, Zhiwei Feng

EpiMII improves MHC-II epitope and neoantigen design by integrating structural features with graph neural networks, achieving higher accuracy and in vivo efficacy in tumor models.

bioRxiv · Apr 29, 2025 · PreprintImmunology

Development of alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell derived liver organoids

Zhiwei Feng, Bingrui Zhou, Qizhi Shuai, Yunliang Wei, Ning Jin, Xiaoling Wang, Hong Zhao, Zhizhen Liu, Jun Xu, Jianbing Mu, Jun Xie

This study develops a human induced pluripotent stem cell-derived liver organoid model of alcoholic liver disease to evaluate drug treatments and replicate key pathological features.

Acta Biochimica et Biophysica Sinica · May 30, 2024Peer-reviewedCell Biology