Author

Nicole Ziak

University of ZurichORCID 0009-0007-0715-2129Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Museer A. LoneiD· 2 shared Thorsten HornemanniD· 2 shared Daniel PuniD· 1 shared Devesh C. PantiD· 1 shared Fuying Ma· 1 shared Janani ParameswaraniD· 1 shared Jie JiangiD· 1 shared Prisha Dutta· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Museer A. LoneORCID

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2 papers

Recent·Most cited

NeuroscienceLife Science AlliancePeer-reviewedJun 20, 2026

Lack of motor defects and ALS-like neuropathology in heterozygous Sptlc1 Exon 2 deletion mice

Devesh C. Pant, Museer A. Lone, Janani Parameswaran…·Jie Jiang

This study creates a mouse model with a heterozygous deletion of Sptlc1 exon 2 and finds no motor defects or ALS-like neuropathology, but homozygous mutants die prematurely.

DOI 10.26508/lsa.202503605

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 3, 2026

Sphingolipid remodelling in SPT-related neuropathies

Nicole Ziak, Thorsten Hornemann, Museer A. Lone

This study compares the metabolic consequences of SPTLC1 and SPTLC2 mutations in different neuropathies, revealing distinct sphingolipid flux patterns associated with ALS, HSAN1, and mixed sensory-motor phenotypes.

DOI 10.64898/2026.04.01.715856

humanstatistical model

𝕏 PostBluesky