Timothy H. Wong

CLIC-dependent internalization of caveolin-1 to lysosomal vacuoles in response to osmotic regulation

The paper shows that caveolin-1 is internalized via CLIC-dependent endocytosis to lysosomal vacuoles in response to osmotic changes, defining a new recycling pathway for membrane buffering.

Adversarial erasing enhanced multiple instance learning (siMILe): Discriminative identification of oligomeric protein structures in single molecule localization microscopy

siMILe identifies condition-specific protein structures from SMLM data by using adversarial erasing and multiple instance learning, showing improved detection of caveolae and structural variations.

Super-resolution single molecule network analysis (SuperResNET) detects changes to clathrin structure by small molecule inhibitors

SuperResNET analyzes single-molecule imaging data to show that Pitstop 2 and Dynasore alter clathrin structure in distinct ways in HeLa cells.

SuperResNET GUI: model-free single molecule network analysis software achieves molecular resolution of Nup96

SuperResNET GUI analyzes single molecule data to reconstruct subcellular structures at molecular resolution without prior models.