Ivan R. Nabi

This study shows Gp78 ubiquitin ligase regulates omegasome formation and mitochondrial protein degradation during mitophagy, independent of PINK1 and Parkin.

The paper investigates how mechanical stress affects caveolae mechanics, leading to the release of caveolin-1 scaffolds and modulation of signaling pathways like JAK1, eNOS, PTEN, and PTP1B.

The paper shows that caveolin-1 is internalized via CLIC-dependent endocytosis to lysosomal vacuoles in response to osmotic changes, defining a new recycling pathway for membrane buffering.

siMILe identifies condition-specific protein structures from SMLM data by using adversarial erasing and multiple instance learning, showing improved detection of caveolae and structural variations.

nERdy and nERdy+ accurately extract and represent ER network dynamics, revealing roles of Atlastin and Reticulon 4 in tubular matrix formation.

HDCluster is a high-degree graph clustering algorithm for SMLM data that efficiently handles large datasets and outperforms existing methods in speed and noise robustness.

SuperResNET analyzes single-molecule imaging data to show that Pitstop 2 and Dynasore alter clathrin structure in distinct ways in HeLa cells.

SuperResNET GUI analyzes single molecule data to reconstruct subcellular structures at molecular resolution without prior models.

This study uses machine learning to distinguish caveolae from scaffolds in SMLM data, achieving high accuracy with random forest and CNN models.

This study identifies Gp78 as an E3 ubiquitin ligase that mediates both basal and damage-induced mitophagy through distinct mechanisms involving mitochondrial homeostasis and PINK1.