Author

Jacob K. Christopher

University of VirginiaORCID 0009-0007-1363-0553Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

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Approach:diffusion model· 1 Research Focus:protein design· 1 Assay:protein structure· 1

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Austin SeamanniD· 1 shared Ferdinando FiorettoiD· 1 shared Jingyi CuiiD· 1 shared Sagar D. KhareiD· 1 shared

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2025-2025 · peak 1/yr

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Austin SeamannORCID

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Molecular BiologybioRxivPreprintOct 15, 2025

Constrained Diffusion for Protein Design with Hard Structural Constraints

Jacob K. Christopher, Austin Seamann, Jingyi Cui…·Ferdinando Fioretto

This paper introduces a constrained diffusion framework for protein design that enforces strict structural constraints while maintaining structural diversity, achieving state-of-the-art results on motif scaffolding and pocket design tasks.

DOI 10.1101/2025.10.15.682365

protein structurediffusion model

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