Austin Seamann

This paper retrained ProteinMPNN on halophilic proteomes to design salt-tolerant enzymes, showing HaloMPNN shifts protein properties toward halophilic traits.

This paper introduces a constrained diffusion framework for protein design that enforces strict structural constraints while maintaining structural diversity, achieving state-of-the-art results on motif scaffolding and pocket design tasks.

This paper identifies geometric and spatial patterns in pancreatic cancer that correlate with aggressive behavior and develops an AI tool to improve clinical evaluation and treatment planning.