Cancer BiologybioRxivPreprint
On-target mutations confer resistance to WRN helicase inhibitors in Microsatellite Unstable Cancer Cells.
Gabriele Picco, Yanhua Rao, Angham Al Saedi…·Mathew J. Garnett
This study identifies on-target WRN mutations as resistance mechanisms in MSI cancer cells to WRN helicase inhibitors and suggests combination therapies to prevent resistance.
3 citations