Cansu Dinçer

The paper uses CRISPR base editing and structural analysis to identify functional residues in the PI3K pathway, revealing potential drug targets and allosteric pockets.

BEstimate designs and interprets CRISPR base editing experiments by predicting gRNA targets, off-targets, and providing functional annotations.

This study identifies on-target WRN mutations as resistance mechanisms in MSI cancer cells to WRN helicase inhibitors and suggests combination therapies to prevent resistance.

CEN-tools identifies context-specific essential genes using CRISPR screen data, revealing gene dependencies across biological contexts and integrating with protein-protein interaction networks.

This study analyzes mutation distribution in GBM tumors using 3D spatial organization and network-guided methods, revealing four patient clusters with distinct mutation patterns and pathways.