Author

Shih-Yun Guu

Institute of Biological Chemistry, Academia SinicaORCID 0009-0007-1886-5140Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Kay‐Hooi KhooiD· 4 shared Abhishek Prakash ShindeiD· 1 shared Alex BennettiD· 1 shared Alois ZdrhaiD· 1 shared Anthony A. KossiakoffiD· 1 shared Brian KlossiD· 1 shared Carmen R. CoriiD· 1 shared Chelsea M. BrowniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

Kay‐Hooi KhooORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 23, 2026

The mannose 6-phosphate receptor system is ancient, widespread in eukaryotes, and functionally diversified in the human parasite Trichomonas vaginalis

Abhishek Prakash Shinde, Harpreet Kaur, Shih-Yun Guu…·Jan Tachezy

The paper identifies the M6P pathway as ancient and widespread in eukaryotes, with functional diversification in Trichomonas vaginalis.

DOI 10.64898/2026.10.22.760878

humanproteomics

𝕏 PostBluesky

NeuroscienceMolecular NeurodegenerationPeer-reviewedOct 1, 2026

Oxidative Stress-Induced Microglial CD22 Upregulation Impairs Phagocytosis and Exacerbates Huntingtons Disease

Yan Hua Lee, Jian Jing Siew, Chia‐Wei Lee…·Yijuang Chern

This study identifies CD22 upregulation in microglia due to oxidative stress in HD, which impairs phagocytosis and worsens disease progression.

DOI 10.1186/s13024-026-00996-4

mouseproteomics

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedNov 25, 2025

Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation

Chunsheng Jin, Jon Lundstrøm, Carmen R. Cori…·Daniel Bojar

This study characterizes the structural and functional dynamics of milk oligosaccharides in Atlantic grey seals throughout lactation, revealing complexity comparable to human milk.

6 citations

non-human primatemetabolomics

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedApr 29, 2025

Structural insights into terminal arabinosylation biosynthesis of the mycobacterial cell wall arabinan

Yaqi Liu, Chelsea M. Brown, Satchal K. Erramilli…·Filippo Mancia

This study presents cryo-EM structures of AftB from Mycobacterium chubuense, revealing its architecture and mechanism for terminal arabinosylation in mycobacterial cell wall biosynthesis.

12 citationstop 2%

cryo-EMexperimental assay

𝕏 PostBluesky