Author

Lorenzo S Cagnin

Boston Children's HospitalORCID 0009-0007-1980-8340Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Elisa Rojas PalatoiD· 2 shared Francesca Alvarez CalderoniD· 2 shared Katherine A. MichaelisiD· 2 shared Kayleigh Ingersoll OmdahliD· 2 shared Leslie S. KeaniD· 2 shared Marlana Winschel· 2 shared Ulrike GerdemanniD· 2 shared Victor TkacheviD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Elisa Rojas PalatoORCID

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2 papers

Recent·Most cited

ImmunologyBlood Immunology & Cellular TherapyPeer-reviewedApr 20, 2026

Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies

Holly Wobma, Francesca Alvarez Calderon, Jiayi Dong…·Leslie S. Kean

This study edits Cyclophilin A's C-terminus using CRISPR/Cas9 to create cell therapies resistant to cyclosporine and voclosporin, preserving function in immune suppression settings.

DOI 10.1016/j.bict.2026.100054

mousegenetic perturbation / CRISPR

𝕏 PostBluesky

ImmunologybioRxivPreprintSep 17, 2025

PTPN2-KO CAR-T Cells Demonstrate Enhanced Effector Function, CNS Infiltration, and Toxicity in a Non-Human Primate CAR-T Model

Francesca Alvarez Calderon, Ryan A. Fleming, Marlana Winschel…·Ulrike Gerdemann

DOI 10.1101/2025.09.17.676426

non-human primatebulk RNA-seq

𝕏 PostBluesky